The mixed lineage leukemia 3 (MLL3) core complex catalyzes monomethylation at histone H3 lysine 4 (H3K4). Unlike in other MLL family core complexes, the WDR5 subunit of the MLL3 core complex inhibits H3K4 methylation activity. The cover shows the BioSAXS solution structures of the MLL3 core complex assembled with WDR5 (purple) superimposed with that of the core complex without WDR5 (blue). These structures give insight into the spatial location of WDR5 (orange) within the MLL3 core complex and its mechanism of inhibition. For more information, see the article by Shinsky and Cosgrove. We thank Victor Garcia of huemanelement.com for help with the cover design.

The data that resulted in these structures were collected at the Cornell University High Energy Synchrotron Source (CHESS) on the G1 beam line. See the CHESS eNewsletter for a nice story about this work. 

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Cosgrove Lab in the News:
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Physician's Weekly
Phase separation Promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation 

ASBMB Today
From the journals: JBC
Phase separation promotes H3K4 methylation

CHESS Cornell High Energy Synchrotron Source
BioSAXS works to uncover cellular machinery involved in regulation of DNA transcription

JBC Papers of the Week
The Multiple Methylation Mystery

AAAS EurekAlert!
Syracuse University Researchers Discover New Way to Attack Some Forms of Leukemia

LabMedica.com
Can Cancer Cells be Reprogrammed Back to Normality?

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The Cosgrove lab is accepting rotation students for Spring 2025.